Dynamics of changes in markers of endogenous intoxication in rats with simulating acute generalized peritonitis on a background of obesity

Abstract

The aim of the work: to study the state of indicators of endogenous intoxication in the body of experimental animals with simulated AGP on the background of obesity and to compare them with groups of animals with obesity and with animals with AGP. Materials and Methods. The experiment used 64 white Wistar rats, which were divided into three groups: the main group – 24 animals with AGP modeling against the background of obesity; the comparison group – 8 animals with modeling of obesity only; another compa­rison group – 24 animals with only AGP simulation; the control group consisted of 8 intact animals kept in standard vivarium conditions. АPP was modeled by injecting 10 % filtered fecal suspension into the abdominal cavity. Obesity was simulated using a high-calorie diet. The content of indicators of endogenous intoxication in the blood of animals was determined using the photospectrometric method. Results and Discussion. It was established that in animals with АGP against the background of obesity, the indicators of lipoperoxidation were significantly activated (by 1.8 times the level of TBА-AP compared to intact animals) and the antioxidant defense was depleted (according to a statistically significantly lower index of superoxide dismutase by 2.4 times compared to the control) ) (p <0.05). Conclusions. The development of AGP is accompanied by the EIS complex, which indicates an increase in catabolic processes in the dynamics of pathology modeling, and is laboratory-detected by a probable increase in the levels of MSM, EII. The depth of endotoxemia in rats increases during all stages of development of acute peritonitis and depends on the presence of accompanying obesity, which is confirmed by significantly higher levels of MM254 and MM280, EII during all observed terms of animals with combined pathology.