COVID-19 IN ADOLESCENT PATIENTS IN THE BRAZILIAN POPULATION WITH SICKLE CELL ANEMIA

Abstract

Introduction: Sickle cell anemia due to recent scientific evidence suggests that individuals with disease are considered a risk group and SARS-CoV-2 and spreads rapidly in this group of patients with diseases due to lack of inherited immunity, has a high lethality rate among young people and children and patients with associated comorbidities such as Diabetes Mellitus. Objective: to analyze the profile of patients with sickle cell anemia and their immunological motivations for worsening in positive cases of COVID-19 from a systematic review. Results: Initially, 217 articles were identified, of which 213 were removed because they were not related to the theme of the review, or because they were duplicated or did not have the abstract. The 04 selected articles were classified into two thematic axes to be performed the analysis. Discussion:  This systematic review study is the first with sickle cell anemia and COVID-19 in the adolescent population with a limited resource configuration that shows the inherent need in the management of both diseases. However, in this systematic review, the four included studies showed a favorable evolution of the infectious process by COVID-19, and deaths occurred in adolescent patients who concomitantly had multiple comorbidities, for example, DM. Conclusion: It was found in this systematic review study that COVID-19 infection may accentuate the presence of vasculopathy in patients with sickle cell anemia and may increase pain to varying degrees.