Abstract
Patients with long-term effects of coronavirus disease, the so-called “long-term COVID-19 syndrome” (long-COVID-19) after SARS-CoV-2 infection, have a postponed recovery lasting from 4 weeks and up to six months, spread worldwide. Physiological predictors based on human blood biomarkers and host-virus responses to SARS-CoV-2 are still unknown. There is growing evidence about the impact of micronutrients on improving lymphocyte proliferation and their essential roles for a functioning human immune system and regulating metabolic health. This paper aims to review information about micronutrients in patients with SARS-CoV-2 infection that determines long-COVID-19 outcomes and highlight the importance of diagnostics in predictors of long-COVID-19. We reviewed articles returned from searches on PubMed/SCOPUS/Web of Science/ EMBASE databases using a combination of terms “long COVID-19”, “long-term effects of COVID-19”, “post-COVID-19 symptoms”, “COVID-19 associated stress”, “micronutrients”. Evidence indicates the relationship between lymphocyte proliferation improving micronutrient level and long-COVID-19 induction. Zinc, selenium, iron, manganese have an immunomodulatory function in innate and adaptive immune responses to viral infection. Anti-inflammatory functions of Vits A and B groups include the regulation of lymphocyte proliferation and metabolic health. Further research using sampling and artificial intelligence-assisted algorithms could assist in the recognition of the correlation of micronutrients and long-COVID-19 clinical outcomes
Publisher
Danylo Halytskyi Lviv National Medical University
Reference43 articles.
1. 1. Schultze JL, Aschenbrenner AC. COVID-19 and the human innate immune system. Cell. 2021 Apr 1.
2. 2. Devaux CA, Rolain JM, Raoult D. ACE2 receptor polymorphism: Susceptibility to SARS-CoV-2, hypertension, multi-organ failure, and COVID-19 disease outcome. Journal of Microbiology, Immunology and Infection. 2020 Jun 1;53(3):425-35.
3. 3. Chopyak Valentina; Lishchuk-Yakymovych Khrystyna; Pukalyak Roman. Immunological aspects of covid-2019: realities and prospects Immunology and Allergy: Science and Practice, 2020, 3-4: 34-41.
4. 4. Fernández-de-Las-Peñas C, Palacios-Ceña D, Gómez-Mayordomo V, Rodríuez-Jiménez J, Palacios- Ceña M, Velasco-Arribas M, Guijarro C, de-la-Llave-Rincón AI, Fuensalida-Novo S, Elvira-Martínez CM, Cuadrado ML. Long-term post-COVID symptoms and associated risk factors in previously hospitalized patients: A multicenter study. Journal of Infection. 2021 Aug 1;83(2):237-79,
5. 5. Carson G. Research priorities for Long COVID: refined through an international multi-stakeholder forum. BMC medicine. 2021 Dec;19(1):1-4.
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