Chemopreventive Effects of Nobiletin against Genotoxicity Induced by 4-(Methylnitrosamino)-1-(3-pyridyl)-1-butanone (NNK) in the Lung of gpt delta Transgenic Mice

Author:

Ikeda Megumi,Masumura Ken-ichi,Matsui Keiko,Kohno Hiroyuki,Sakuma Keiko,Tanaka Takuji,Nohmi Takehiko

Publisher

Japanese Environmental Mutagen Society

Subject

Environmental Science (miscellaneous),Genetics,Social Psychology

Reference45 articles.

1. 1 Tobacco smoking. IARC Monogr Eval. Carcinog. Risk Chem. Hum. 1986; 38: 35-394. Lyon, France, International Agency for Research on Cancer.

2. 2 Hecht SS, Carmella SG, Foiles PG, Murphy SE. Biomarkers for human uptake and metabolic activation of tobacco-specific nitrosamines. Cancer Res. 1994; 54: 1912s-17s.

3. 3 Hecht SS, Hoffmann D. Tobacco-specific nitrosamines, an important group of carcinogens in tobacco and tobacco smoke. Carcinogenesis. 1988; 9: 875-84.

4. 4 4-(Methylnitrosamino)-1-(3-pyridyl)-1-butanone (NNK). IARC Monogr Eval. Carcinog. Risk Chem. Hum. 1985; 37: 209-23. Lyon, France, International Agency for Research on Cancer.

5. 5 Ronai ZA, Gradia S, Peterson LA, Hecht SS. G to A transitions and G to T transversions in codon 12 of the Ki-ras oncogene isolated from mouse lung tumors induced by 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone (NNK) and related DNA methylating and pyridyloxobutylating agents. Carcinogenesis. 1993; 14: 2419-22.

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