Author:
Pipitone R. Nathan,Banai Benjamin,Walters Jessica,Dautrich Tyler,Schuller Kelly,Rosenthal Martha
Abstract
Objective: Recent scientific attention has focused on the therapeutic effectiveness of cannabis use on a variety of physical and mental ailments. The present study uses smartphone technology to assess self-reported experiences of Florida cannabis users to understand how cannabis may impact anxiety and depression symptomatology. Method: Several hundred Releaf AppTM users from the state of Florida provided anonymous, real-time reports of their symptoms of anxiety and/or depression immediately before and after cannabis use sessions. Linear mixed-effects modeling was used to analyze the data at the symptom and user level. Results: Results showed that for the majority of users, cannabis use was associated with a significant decrease in depression and anxiety symptomatology. While symptom type, doses per session, consumption method, and CBD levels were significant predictors of relief change, their effect sizes were small and should be interpreted with caution. At the user level, those who had positive relief outcomes in anxiety reported more doses and sessions, and those in the depression group reported more sessions. Conclusions: Our results generally support the therapeutic effectiveness of cannabis against depression/anxiety symptomatology. Future work should include standardized statistics and effect size estimates for a better understanding of each variable’s practical contribution to this area of study.
Publisher
Research Society on Marijuana
Reference50 articles.
1. Andrade, A.K., Renda, B., & Murray, J.E. (2019). Cannabinoids, interoception, and anxiety. Pharmacology, Biochemistry, and Behavior, 180, 60-73. https://doi.org/10.1016/j.pbb.2019.03.006
2. Endocannabinoid system dysfunction in mood and related disorders;Ashton;Act Psychiatrica Scandinavica,2011
3. Bates, D., Mächler, M., Bolker, B., & Walker, S. (2014). Fitting linear mixed-effects models using lme4. arXiv preprint arXiv:1406.5823. https://doi.org/.48550/arXiv.1406.5823
4. Brody, D. & Qiuping, G. (2020, September 4). Antidepressant use among adults: United States, 2015-2018. NCHS Data Brief, 377. https://www.cdc.gov/nchs/products/databriefs/db377.htm
5. Centers for Disease Control and Prevention (CDC). (2018). National Ambulatory Medical Care Survey: 2018 National Summary Tables. Table 23. https://www.cdc.gov/nchs/data/nhamcs/web_tables/2018-ed-web-tables-508.pdf