The effect of quercetin, a flavonoid, on lung injury caused by sepsis-Reference-Cited by-同舟云学术

The effect of quercetin, a flavonoid, on lung injury caused by sepsis

Published:2023-09-29 Issue:9 Volume:7 Page:618-622
ISSN:2602-2079
Container-title:Journal of Surgery and Medicine
language:
Short-container-title:J Surg Med

Author:

Bıçakcıoğlu Murat^ORCID,Doğukan Mevlüt^ORCID,Duran Mehmet^ORCID,Doğan Zümrüt^ORCID,Aydın Türk Bilge^ORCID

Abstract

Background/Aim: Lung injury is frequently observed in cases with sepsis, which can lead to conditions that progress to acute respiratory distress syndrome (ARDS) causing mortality. There is no specific treatment for sepsis or sepsis-induced lung injury. Antioxidant therapy has been one of the most prominent options for treatment, according to pathophysiological studies. The aim of this study was to investigate the effects of quercetin, a powerful antioxidant, on sepsis and sepsis-related lung injury. Methods: Thirty-two adult male Sprague Dawley rats were divided into five groups. The control group (CNRL) received 1.5 ml saline via the intragastric route. The quercetin group (QUER [n=5]) underwent no sepsis procedure and received 20 mg/kg quercetin via the intragastric route starting 15 days before the procedure. The sham group (SHAM [n=6]) underwent a surgical incision and received 1.5 ml intragastric olive oil (quercetin dissolves in oil). The sepsis group (SEPS [n=7]) underwent the sepsis procedure. The sepsis and quercetin group (SEPS+QUER [n=7]) underwent the sepsis procedure and received 20 mg/kg quercetin via the intragastric route for 15 days before the procedure. Cecal ligation and puncture methods were used to induce sepsis. While ALT, AST, LDH, GGT and CRP values were analyzed from rat blood, MDA and GSH levels were analyzed from lung tissue. Results: The results showed that quercetin reduced neutrophil infiltration (TLIS 3.5 [0.26] in the SEPS group vs TLIS 2.75 [0.29] in the SEPS+QUER group [P=0.01]), intra-alveolar macrophage count (SEPS vs SEPS+QUER [P=0.01]) and cell proliferation (SEPS vs SEPS+QUER [P=0.01]), and that it helped to preserve lung anatomy during sepsis. It was observed that MDA levels in the lung tissue decreased with the treatment of quercetin to septic rats (SEPS vs SEPS+QUER [P=0.046]). Conclusion: These findings suggest that quercetin may be a potential treatment option for sepsis. However, more studies are needed to determine whether quercetin is a viable option as a therapeutic strategy in patients.

Publisher

SelSistem

Subject

General Engineering

Reference29 articles.

1. Rhodes A, Evans LE, Alhazzani W, Levy MM, Antonelli M, Ferrer R, et al. Surviving Sepsis Campaign: International Guidelines for Management of Sepsis and Septic Shock: 2016. Intensive Care Med. 2017;43(3):304-77. doi: 10.1007/s00134-017-4683-6.

2. Zhang HB, Sun LC, Zhi LD, Wen QK, Qi ZW, Yan ST, et al. Astilbin alleviates sepsis-induced acute lung injury by inhibiting the expression of macrophage inhibitory factor in rats. Arch Pharm Res. 2017;40(10):1176-85. doi: 10.1007/s12272-016-0857-y.

3. Yeh CH, Yang JJ, Yang ML, Li YC, Kuan YH. Routine decreases lipopolysaccharide-induced acute lung injury via inhibition of oxidative stress and the MAPK-NF-κB pathway. Free Radic Biol Med. 2014;69:249-57. doi: 10.1016/j.freeradbiomed.2014.01.028.

4. Gerin F, Sener U, Erman H, Yilmaz A, Aydin B, Armutcu F, et al. The Effects of Quercetin on Acute Lung Injury and Biomarkers of Inflammation and Oxidative Stress in the Rat Model of Sepsis. Inflammation. 2016;39(2):700-5. doi: 10.1007/s10753-015-0296-9.

5. Huang R, Zhong T, Wu H. Quercetin protects against lipopolysaccharide-induced acute lung injury in rats through suppression of inflammation and oxidative stress. Arch Med Sci. 2015;11(2):427-32. doi: 10.5114/aoms.2015.50975.