Comparison of two anastomosis techniques in terms of postoperative pancreatic fistula development: A retrospective cohort study

Author:

Çiçek Okuyan GültenORCID,Talu MehmetORCID

Abstract

Background/Aim: Postoperative pancreatic fistula (POPF) development is a common complication after pancreaticoduodenectomy. Various surgical anastomosis techniques have been proposed to mitigate this risk. This study compares two techniques: the two-layer duct-to-mucosa pancreaticojejunostomy (TLPJ) and the modified layer-to-layer end-to-side duct-to-mucosa pancreaticojejunostomy with jejunal serosa resection (MLLPJ). Methods: A retrospective cohort study was conducted on patients who underwent pancreaticoduodenectomy between January 2012 and December 2020. The primary outcome was the rate of biochemical leak and clinically relevant POPF (grades B and C POPFs). Results: The rate of biochemical leak was significantly higher in the TLPJ group than in the MLLPJ group (54.5% vs. 4.0%, P<0.001). Clinically relevant POPFs developed in 5.2% of all patients, with rates of 6.1% in the TLPJ group and 4.0% in the MLLPJ group. Patients with longer surgery durations, increased bleeding, and a soft pancreas texture had significantly higher risk of developing clinically relevant POPFs (P=0.009, P=0.039, and P=0.022, respectively). Conclusion: The MLLPJ anastomosis technique demonstrated a significant reduction in biochemical leak rates. However, the choice between TLPJ and MLLPJ did not significantly impact the rates of clinically relevant POPFs. Other factors, such as surgery duration, bleeding volume, and pancreas texture, were identified as significant risk factors for the development of these fistulas.

Publisher

SelSistem

Subject

General Engineering

同舟云学术

1.学者识别学者识别

2.学术分析学术分析

3.人才评估人才评估

"同舟云学术"是以全球学者为主线,采集、加工和组织学术论文而形成的新型学术文献查询和分析系统,可以对全球学者进行文献检索和人才价值评估。用户可以通过关注某些学科领域的顶尖人物而持续追踪该领域的学科进展和研究前沿。经过近期的数据扩容,当前同舟云学术共收录了国内外主流学术期刊6万余种,收集的期刊论文及会议论文总量共计约1.5亿篇,并以每天添加12000余篇中外论文的速度递增。我们也可以为用户提供个性化、定制化的学者数据。欢迎来电咨询!咨询电话:010-8811{复制后删除}0370

www.globalauthorid.com

TOP

Copyright © 2019-2024 北京同舟云网络信息技术有限公司
京公网安备11010802033243号  京ICP备18003416号-3