Efficacy and Safety of Local Psoralen-UVA Treatment in Palmoplantar Dermatoses: A Single-Center Retrospective Study

Abstract

Local PUVA is one of the treatments used for resistant cases in palmoplantar dermatoses. In this study, we aimed to evaluate the efficacy and safety of local PUVA in the treatment of palmoplantar dermatoses. A total of 115 patients who were treated with local PUVA with the diagnosis of palmoplantar dermatosis (palmoplantar psoriasis, contact dermatitis, palmoplantar keratoderma, dyshidrotic eczema) were included in the study. The mean maximum single dose was 4.83 ± 2.55 and the mean cumulative UVA dose was 171.30 ± 176.77. Treatment response was evaluated in 78 (67.8%) of the patients; 37 (32.2%) patients were lost to follow up. When the treatment response was evaluated, 58 (74.35%) patients achieved a complete response; 15 (19.23%) patients achieved a partial response, and 5 (6.41%) patients had no response to the treatment. There was no significant difference between diseases in terms of gender and age distribution, disease duration, mean duration of treatment, number of sessions and response to treatment between groups. Erythema was the most common adverse effect and was observed in 16 (13.9%) of the patients. In conclusion, local PUVA treatment is an effective and safe treatment option in palmoplantar dermatoses that reduces the need for topical steroids and other systemic treatments.