Systemic inflammatory response index (SIRI) and Systemic immune-inflammation index (SII) to show Thrombus Localization in Patients with Acute Pulmonary Embolism

Abstract

Pulmonary embolism (PE) is a critical disease associated with mortality. Considerable markers related to this disease associated with inflammation have been used to catch thrombus localization. In this study, we wanted to examine the association between the Systemic inflammatory response index (SIRI), Systemic immune-inflammation index (SII) and thrombus localization in patients with PE. Our study consisted of patients diagnosed with PE between January 2020- June 2022. Laboratory parameters of patients diagnosed with PE, especially thrombus localization, thrombus location, SII, and SIRI, were recorded and compared with thrombus localization. One hundred patient with PE who met the inclusion criteria was incorporated in our study. When we grouped the patients according to PE localization, the thrombus was in the main pulmonary vein in 18%, in the lobar region in 51%, and in the distal pulmonary vein in 31% of the patients. In addition, mean SIRI and SII levels were encountered to be higher in patients with main pulmonary localization compared to those with thrombus in both lobar and segmental branches. SIRI has 78% sensitivity, and 72% specificity at the optimum cut-off value; in Level II, it detects thrombus with main pulmonary involvement with 66.7% sensitivity and 79.3% specificity. In patients with PE, high SII and SIRI values can be practical markers in predicting proximal thrombus.