Lung fibrosis molecular mechanisms

Abstract

Lung fibrosis is a highly heterogeneous and life-threatening disease in patients. Studies on the molecular pathogenesis of lung fibrosis have more often focused on the mechanisms regulating the increase of extracellular matrix and collagen. Although these studies have been conducted in this way, many different new studies are also being conducted. These studies have focused more on the mechanisms regulating fibroblast activation and differentiation, how fibrosis starts and how it progresses. In this review, especially the molecular mechanisms of lung fibrosis are emphasized and examined.