Prediyabet Durumunda Kardiyovasküler Riskin Öngörülmesi: Bozulmuş Açlık Glukozu Olan Bireylerde Aterojenik Plazma İndeksinin Rolü

Abstract

Atherogenic plasma index (API) is a relatively new index used in the general population for predicting the risk of cardiovascular disease. High fasting plasma glucose (FPG) levels have been shown to be associated with diabetes mellitus and metabolic syndrome, and API. However, no study has been conducted on the relationship between impaired fasting glucose identified using fasting and 2-hour plasma glucose in the oral glucose tolerance test, hemoglobin A1c (HbA1c) levels, and API. API was calculated using the logarithm of the molar ratio of triglycerides to high-density lipoprotein cholesterol. The relationship between glucose metabolism parameters with diabetes status and API was analyzed. The frequency of prediabetes and diabetes in the study participants was 35.3% (n=58) and 25.3% (n=40), respectively. 40 individuals were identified as Type 2 diabetes (fasting glucose >125 mg/dl, OGTT 2nd hour >200 mg/dl), 58 as impaired fasting glucose (IFG) prediabetes (fasting glucose: 100-125 mg/dl, OGTT 2nd hour <140mg/dl), and 66 individuals as a non-diabetic control group (glucose <100 mg/dL). 28.1% of participants were in the low-risk group (API<0.11), 18.2% were in the medium-risk group (API 0.11-0.21), and 53.6% were in the high-risk group (API>0.21). High API (high-risk group) was found to be significantly associated with prediabetes and diabetes status. API was also significantly associated with HbA1c, FPG, and 2-hour plasma glucose levels in the OGTT. AIP was significantly associated with the param¬eters of diabetes and prediabetes. Simple calculations made from fasting lipid panel results can be provide more information in assessing the risk of cardiovascular disease with IFG patients in prediabetes status.