A HOSPITAL BASED STUDY IN TERTIARY CARE CENTRE IN NORTH INDIA: PREVALENCE OF NAFLD IN PATIENTS OF PREDIABETES AND DIABETES

Abstract

Background: Non-alcoholic fatty liver disease (NAFLD) is the most common liver disease in developed countries and now becoming in developing countries also. Central Obesity and sedentary life style is usually associated with NAFLD.There are a lot of study has been done regarding prevalence of NAFLD in diabetes but lesser study available for prediabetes. In different studies reviewed by us, prevalence of NAFLD in diabetic subjects has been reported to range from 26.5% to 86.7%1,2,3. In prediabetic patients this prevalence has been seen to range from 48.24% to 68%4,5,6. OBJECTIVE: To assess the prevalence of Non-Alcoholic Fatty Liver Disease (NAFLD) in prediabetes and diabetes patients. RESEARCH DESIGN AND METHODS: A cross sectional study was conducted at SRN Hospital, Prayagraj. A total of 100 prediabetic and 100 diabetic patients were enrolled in the study. Patients on the basis of HbA1c(glycated hemoglobin) are divided in to two groups, prediabetic and diabetic group. Patients with known case of liver disease, taking steroid and regular alcohol intake were excluded from study. Ultrasonography B mode used for detection of fatty liver inltration and their grading. RESULT: Prevalence of NAFLD was 48% in prediabetic and 54% in diabetic group. In prediabetic group, 32% had grade 1, 13% had grade 2 and 3% had grade 3 NAFLD whereas in diabetic group 34% had grade 1, 18% had grade 2 and 2% had grade 3 NAFLD. In the present study, we found that diabetic patients as compared to pre-diabetic patients were signicantly older, had a higher proportion of males and higher BMI(Body mass index). Conclusion: There was no signicant difference between two groups for association of NAFLD and its severity. Higher BMI is associated with higher chances to get NAFLD and diabetes mellitus in future.