Affiliation:
1. MPH, MD
2. MD, Additional Professor, Department of Pathology, KGMU
3. MD
4. PhD
5. MS
Abstract
Background: Peripheral lymphadenopathy is frequently due to a local or systemic, benign, self-limited, infectious disease or malignancy.
Cervical lymph nodes are involved more often than the other lymphatic regions. In India tuberculosis (TB) is a major benign cause in adults and
children. Some studies have been conducted to assess sero prevalence of toxoplasmosis, another infectious disease of signicance. The clinical
overlap of spectrum between various diseases like early TB, sarcoidosis and toxoplasmosis has led us to investigate in this grey zone.
Methodology: FNAC from enlarged cervical nodes of 100 patients was done. DNA extraction from the aspirate and Antigen –antibody reaction
(ELISA) on serum samples was done on 49 patients who showed granulomatous pathology on cytology smears, out of 100 samples collected.
Results: There were no IgM antibodies detected in any serum sample. IgG was detected in 7 cases. PCR on the lymph node aspirates did not show
any presence of B1 gene of Toxoplasma. We recommend that a differential of Toxoplas Conclusion: ma be kept as a possible diagnosis when Zeihl
Neelsen does not detect AFB on the granulomatous lymphadenopathies. Serologic conrmation in all suspected cases of this self-limited condition
should be done, for which no treatment is necessary
Subject
General Dentistry,Information Systems,Theoretical Computer Science,Software,Computer Networks and Communications,Software,Artificial Intelligence,Computer Vision and Pattern Recognition,Software,Mechanics of Materials,Civil and Structural Engineering,Mechanics of Materials,Civil and Structural Engineering,Education,Developmental and Educational Psychology,Education,Biochemistry,Drug Discovery,Molecular Medicine,Biochemistry,Bioengineering,Analytical Chemistry
Reference12 articles.
1. M. Dhumne, C. Sengupta, G. Kadival. A. Rathinaswamy and A. Velumani. National Seoprevalance of Toxoplasma gondii in India. Journal of Parasitology 2007;93(6):1520-1521
2. Mittal V, Bhatia R, Sehgal S. Prevalance of toxoplasma antibodies among women with BOH and general population in Delhi. The Journal of Communicable Diseases. 1990; 22(3):223-226
3. Shahrzad Mohseni, Abolfazl Shojaiefard, Zhamak Khorgami, Shahriar Alinejad, Ali Ghorbani, and Ali Ghafouri. Peripheral Lymphadenopathy: Approach and Diagnostic Tools Iran J Med Sci. 2014 Mar; 39(2 Suppl): 158–170.PMCID: PMC399304.
4. Dorfman RF, Remington JS. Value of lymph-node biopsy in the diagnosis of acute acquired toxoplasmosis. N Engl J Med 1973;289:878–81. [PubMed]
5. Miettinen M, Saxen L, Saxen E. Lymph node toxoplasmosis. Follow-up of 237 histologically diagnosed and serologically verified cases. Acta Med Scand 1980; 208:431–6. [PubMed]