THE RELATIONSHIP BETWEEN DIFFERENT DIABETIC FACTORS IN IMPAIRED FASTING PLASMA GLUCOSE OBESE ELDERLY

Abstract

Background: In both developed and developing countries, the relationship between aging an obesity is similar and studies appear to be more important at all ages. Therefore, we focused on patients with impaired fasting blood glucose levels to see the baseline changes in insulin homeostasis. The current study seeks to explain the relationship between insulin secretion, insulin resistance, and glucose effects in obese elderly people. Methods: We randomly enrolled 31subjects who were aged 65 years old. All these patients were obese (body mass index ≥ 25 2 kg/m ) and the fasting plasma glucose (FPG) was between 100 and 125 mg/dl. Four diabetic factors were calculated and included rst phase insulin secretion (PFIS), second phase insulin secretion (SFIS), insulin resistance (IR) and glucose effectiveness (GE). Results: In the current study, we enrolled 18 male and 13 female subjects. The mean FPG was 108 (mg/dl) in both male and female. All the demographic data were non-signicant when compared with male and female except the hemoglobin. When we compared these four diabetic factors with FPG, we found only SPIS was signicantly negative correlated with FPG in both genders. Discussion: FPG was correlated with SPIS only. FPIS, IR and GE were not correlated with FPG in impaired fasting plasma glucose obese elderly. Further study is needed for understating the underlying mechanisms.