LEVELS OF SERUM TSH AND ITS IMPLICATIONS IN DEVELOPMENT OF METABOLIC SYNDROME – TIP OF THE ICEBERG: IN YOUNG ADULTS OF GUWAHATI CITY.

Abstract

Thyroid Stimulating Hormone (TSH) is a hormone secreted by the anterior pituitary that plays an important role in regulating the function of the thyroid gland. Levels of TSH in the blood - is a reliable index of the functional status of the thyroid gland. At present, TSH levels in serum are estimated by microparticle enzyme immuno assays (MEIA), which are very sensitive. In the current study, serum TSH levels were measured in 100 clinically euthyroid subjects, consisting of 50 males and 50 females. The study found that 12% of the subjects (5 males and 7 females) had TSH values above the normal, the normal range of the TSH assay being 0.35-4.50 m IU/ml. This nding is signicant in light of the recent focus on subclinical hypothyroidism being in limelight, particularly the risk of development of overt thyroid dysfunction in persons with high normal values of serum TSH. Furthermore, such kind of studies in general population among young population was done rarely previously, as a reection of their serum TSH levels in this part of the India who are considered euthyroid till the time they were tested. Moreover, detection of subclinical or overt hypothyroid state helps in the preventive aspects as well as to nd out other parameters of metabolic syndrome- which is considered now as just the tip of the iceberg. In the study, serum TSH levels were measured in 100 eut Materials and methods: hyroid subjects (50 males and 50 females) by microparticle enzyme immune assay. After analyzing the values of TSH i Results: t was detected that 12% of the subjects (5 males and 7 females) had TSH levels >4.50 m IU/ml (Upper limit of the normal range). This nding is Conclusion: signicant in light of the recent focus on subclinical hypothyroidism being particularly at the risk of development of overt thyroid dysfunction in young age leading to a gamut of metabolic disorders and mortality & morbidity occuring among such populace at a young age Further, it is of importance that such type of lifestyle modiable disorders can be prevented or reverted to normal if detected early.