ABNORMALITY IN SERUM CALCIUM, PHOSPHATE AND VITAMIN-D LEVELS IN CHRONIC RENAL FAILURE PATIENTS: A CASE CONTROL STUDY IN THE EASTERN INDIAN POPULATION

Abstract

Chronic renal failure (CRF) is one of the most important health problems in our population. From the early stages of the disease progression, the activation of Vitamin D in kidney is affected, resulting in abnormality in the regulation of calcium and phosphate homeostasis in the blood. In the present study, 30 Chronic Renal Failure patients visiting Nephrology OPD and 30 age and sex matched volunteers were studied. Serum levels of Urea, Creatinine, Calcium, Phosphate and Vitamin D were measured in the study participants. The data after statistical analysis showed signicantly higher levels of Phophate and signicantly lower levels of Calcium and Vitamin D in the CRF patients in comparison to healthy control subjects. Phosphate and Vitamin D also shows signicant correlation with serum creatinine levels in the CRF patients. The present study conrms the abnormality in Calcium-Phosphorus metabolism as a complication of CRF in our population, and highlights the importance of regularly measuring these parameters in CRF patients and possible need of taking corrective measures in this regard.