PRIMARY SPLENIC LYMPHOMA: CAN TRUCUT BIOPSY AND R-CHOP SUPERSEDE SPLENECTOMY?

Author:

Sawhney Aanchal1,Khataniar Mridusmita2,Verma Roopal2

Affiliation:

1. Junior resident, Rajiv Gandhi cancer institute, New Delhi.

2. Senior Resident, Department of internal medicine, Sir Ganga Ram Hospital, New Delhi.

Abstract

Primary Splenic lymphoma is a rare type of Non Hodgkin’s lymphoma of the spleen with or without splenic hilar lymph nodes with preservation of other organ systems. In this case, we encountered a patient who presented with fever of unknown origin since 25 days and was diagnosed with Primary splenic lymphoma based on a tru cut biopsy which was then confirmed by immunohistochemistry. Patient was treated with Chemotherapy alone and showed no recurrence after 6 months of follow up. The aim of reporting this case is to have a high index of suspicion for rare malignancies like PSL in cases of FUO. Contrary to the current guidelines, use of trucut biopsy can be used as a promising investigation to diagnose PSL and treatment with chemotherapy with R-CHOP regimen alone prevented recurrence of the tumour. Investigations like PET-CT which have 100% accuracy in diagnosing PSL can reduce the number of operative procedures like splenectomy used for its diagnosis and treatment.

Publisher

World Wide Journals

Reference10 articles.

1. 1. Dasgupta T, Coombes B, Brasfield Rd. Primary malignant neoplasms of the spleen. Surg Gynecol Obstet. 1965;120:947 960.

2. 2. Cavanna L, Artioli F, Vallisa D, et al. Primary lymphoma of the spleen. Report of a case with diagnosis by fine-needle guided biopsy. Haematologica. 1995;80(3):241-243

3. 3. Doshi, K., Stanciu, J., Cervantes, J., Rodrigues, L., Gintautas, J., & Alwani, A. (2008). Splenic non-Hodgkin's lymphoma presenting as recurrent kidney stones -- an "incidentaloma"?. Proceedings of the Western Pharmacology Society, 51, 55–57.

4. 4. Gobbi, P. G., Grignani, G. E., Pozzetti, U., Bertoloni, D., Pieresca, C., Montagna, G., & Ascari, E. (1994). Primary splenic lymphoma: does it exist?. Haematologica, 79(3), 286–293.

5. 5. Sun, P. G., Cheng, B., Wang, J. F., & He, P. (2017). Fever of unknown origin revealed to be primary splenic lymphoma: A rare case report with review of the literature. Molecular and clinical oncology, 6(2), 177–181. https://doi.org/10.3892/mco.2016.1110.

同舟云学术

1.学者识别学者识别

2.学术分析学术分析

3.人才评估人才评估

"同舟云学术"是以全球学者为主线,采集、加工和组织学术论文而形成的新型学术文献查询和分析系统,可以对全球学者进行文献检索和人才价值评估。用户可以通过关注某些学科领域的顶尖人物而持续追踪该领域的学科进展和研究前沿。经过近期的数据扩容,当前同舟云学术共收录了国内外主流学术期刊6万余种,收集的期刊论文及会议论文总量共计约1.5亿篇,并以每天添加12000余篇中外论文的速度递增。我们也可以为用户提供个性化、定制化的学者数据。欢迎来电咨询!咨询电话:010-8811{复制后删除}0370

www.globalauthorid.com

TOP

Copyright © 2019-2024 北京同舟云网络信息技术有限公司
京公网安备11010802033243号  京ICP备18003416号-3