Affiliation:
1. Professor of Paediatrics
2. Associate Professor
3. Assistant Professor
4. Post Graduate
Abstract
Aims: To study the role of surfactant therapy in meconium aspiration syndrome and its outcome in tertiary
care hospital. Objectives: To evaluate the efcacy of surfactant in the treatment of term and near term
infants with meconium aspiration syndrome and their outcome in terms of duration and outcome of ventilation, duration of
oxygen requirement,complications associated with meconium aspiration syndrome. Material and methods: 64 neonates
admitted in NICU, King George Hospital, Visakhapatnam with symptoms of MAS were enrolled in the study, of them 32 were
given surfactant and were taken as cases,32 were not given surfactant and enrolled as controls. Data on APGAR, need for
resuscitation, baby weight, gestational age and laboratory prole were recorded. Those babies with downe's score >7 were
given high dose(4ml/kg) of surfactant and were followed up. Results: There was a rapid fall in oxygenation index in 24hrs after
administration of surfactant and improvement in PaO2/PAO2. In surfactant group mean duration of ventilation, oxygen
supplementation after extubation and length of hospital stay were all signicantly low as compared to control groups.
Conclusion: Surfactant administration improved PaO2/PAO2 signicantly in comparison to the control group with in 24 hours
after delivery, indicating that surfactant aids in improving gaseous exchange at the alveolar capillary barrier in lungs.
Subject
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