COMPARATIVE STUDY OF INTRATHECAL HYPERBARIC BUPIVACAINE 0.5% VERSUS MIDAZOLAM PLUS HYPERBARIC BUPIVACAINE 0.5% MIXTURE FOR INFRAUMBILICAL SURGERIES.

Abstract

Background: Sub arachnoid block is a commonly used anesthesia technique for all infra umbilical surgeries & there is search for agents and techniques which would prolong local anesthetic action without its deleterious effects. The present study was designed to compare effect of 0.5% of hyperbaric bupivacaine intrathecal versus 0.4ml of intrathecal midazolam with 0.5% of hyperbaric bupivacaine for infra umbilical surgeries. Material And Methods: Present study was single-center, a double-blind trial, conducted in patients of age group 18-60 years with ASA grade I/II posted for elective infraumbilical surgery. 60 patients were divided into Group I received 3ml of 0.5% Bupivacaine heavy and 0.4 ml of 0.9% saline & Group II received 3ml of 0.5% Bupivacaine heavy and 0.4 ml of midazolam (2mg). The meanResults: duration of maximum sensory blockade, maximum motor blockade was more in group II as compared to group I & difference was statistically signicant (p<0.05). Mean duration of surgery was less in group II as compared to group I & difference was statistically signicant (p<0.05). Duration of Motor blockade, duration of sensory blockade, time for two segment regression, time of rescue analgesia was more in group II as compared to group I & difference was statistically signicant (p<0.05). Patients complained of pain faster in Group I than in Group II, VAS score. Midazolam still nds a place in regularConclusion: clinical use as an intrathecal adjuvant with hyperbaric bupivacaine due to its hemodynamic stability and better post-operative analgesia with no signicant adverse effects.