Affiliation:
1. (Professor General Surgery) Deccan College of Medical Sciences
2. (Associate Professor Surgical Gastroenterology) Deccan College of Medical Sciences.
3. (Assiatant Professor General Surgery) Deccan College of Medical Sciences
4. (Resident General Surgery) Deccan College of Medical Sciences
5. (Resident Pathology) Deccan College of Medical Sciences
Abstract
IntroductionTumors arising from the mesenchymal layer of the gastrointestinal tract are classied as gastrointestinal stromal tumors or
neuroendocrine tumors based on the immunohistochemical markers they express and the hormones they produce. They are often diagnosed
postoperatively on histopathology. This study aimed to examine the clinical presentation, diagnosis, and management of mesenchymal gut tumors
in a tertiary care center in a low-income country. We conducted a retrospective study of histopathol Patients and methods ogical reports of gut
resection specimens (excluding nonspecic appendicitis) collected from patients diagnosed with gastrointestinal stromal tumors and
neuroendocrine tumors treated at our facility from 2017 to 2021. We evaluated clinical presentation, diagnosis, and management. Of 38 Results
gastrointestinal resection specimens, we found seven patients with gut mesenchymal tumors (two in the foregut, ve in the midgut). There were no
hindgut mesenchymal tumors. Five were gastrointestinal stromal tumors, and two were neuroendocrine tumors (one in the foregut and one in the
midgut). All tumors were resected entirely. Two patients underwent postoperative adjuvant chemotherapy. All patients were disease-free at
follow-up (range, eight months to four years). Gut mesenchymal tumors clinically prese Conclusion nted with nearly the same features as those of
more common pathologies like intestinal tuberculosis. The gut mesenchymal tumors had good prognosis after adequate surgical resection
irrespective of histological type and grade of the tumor. Adjuvant chemotherapy seemed to provide no additional benet, and in primary
completely resectable tumors, it is probably redundant and not economically viable.