Author:
Kumar Randhir,Shakib Ahmad,Chaturvedi Mridul,Maurya Pavan
Abstract
Subclinical hypothyroidism is a very common entity in Indian middle aged population with a prevalence of around 6-15%, dened as increase in
thyroid stimulating hormone (TSH) level without obvious rise in free triiodothyronine (FT3) and free thyroxine (FT4) level. However most of the
patients have an annual conversion of 5% into overt hypothyroidism. Replacement of thyroxine in these patients is always a controversial issue,
deranged lipid prole is an important indication of thyroxine replacement in these patients. In present study which is a case control study, we have
observed improvement in lipid prole after thyroxine replacement in patients of subclinical hypothyroidism with deranged lipid prole. In our
study there is a signicant improvement in total cholesterol, triglyceride, and LDL level without signicant improvement in HDL level after
thyroxine replacement.