PREOPERATIVE ONDANSETRON VERSUS METOCLOPRAMIDE FOR PREVENTION OF NAUSEAAND VOMITING IN ELECTIVE LOWER SEGMENT CAESAREAN SECTION (LSCS) UNDER SPINALANAESTHESIA

Abstract

INTRODUCTION: Post Operative Nausea and Vomiting (PONV) are the most common distressing symptom after LSCS. Antiemetic drugs play an important role to prevent it. Though many drugs have been tried as prophylaxis and treatment of PONV, no drug has been proved signicantly effective and hence, the present study was undertaken to compare the efcacy and safety of IVmetoclopramide and IVOndansetron as prophylaxis for postoperative nausea and vomiting in LSCS under spinal Anaesthesia OBJECTIVES: To study comparison of IV Ondansetron and IV Metoclopramide for prevention of postoperative nausea and vomiting as well as to compare any adverse effect occurrence through drugs in elective LSCS under spinal Anaesthesia. METHODS: It was a prospective study in which 100 patients were selected and randomly allotted into 2 groups, 50 patients in each group, according to inclusion criteria. Group A: Inj. Ondansetron 0.15 mg/kg i.v. Group B: Inj. Metoclopramide 0.25 mg/kg i.v. RESULT: Mean Age, Weight and Duration of surgery are comparable in both the groups without any statistical signicant difference. Incidence of nausea was 12% in group B and there was no incidence of nausea in group A in 30 min after injecting drugs. The incidence of nausea was 14% in group Aand 28% in group B in 45 min after injecting drugs. Incidence of vomiting was 16% in group B and there was no incidence of vomiting in group Ain 30 min after injecting drugs. The incidence of vomiting was 8% in group Aand 22% in group B in 45 min after injecting drugs CONCLUSION: Efcacy and safety of ondansetron is more than metoclopramide for prevention of nausea and vomiting in LSCS under spinal Anaesthesia