CEREBRAL BLOOD FLOW ASSESSMENT BY TRANSCRANIAL DOPPLER TO EVALUATE THE PERCENTAGE OF HIGH RISK OF STROKES IN SICKLE CELL ANEMIA PATIENTS – A CROSS SECTIONAL OBSERVATIONAL STUDY

Abstract

Ÿ 1. AIMS AND OBJECTIVES :To assess the proportion of high risks of stroke in sickle cell disease patients using Transcranial Doppler ndings. Ÿ To assess the abnormal time average mean of maximum velocity in cerebral blood vessels so as we can prevent future stroke by giving proper treatment. 2. Materials and Methods: In our cross-sectional- observational study, 164 patients of age group 2 to 16 years have sickle cell disease were referred to radiology department. After taking informed consent, Transcranial Doppler of the patients was done either transtemporal or transforamenal approach. Data obtained from the study will be subjected to appropriate statistical analysis so as to facilitate interpretation and P-Values were found out. P-Value<0.05 was considered to be statistically signicant. Ÿ 3. Results: Among 164 patients, 106 are male and 58 are female, from which 37 % of male and 27% of female are at high risk, considering the haemoglobin level in normal range. Ÿ In Transcranial Doppler study, we found out that from 164 patients, 108 are normal, 39 are conditional risk and 17 are at high risk of stroke. Ÿ After interpretation, the patients how have the values of TAMMV of MCA and/or ICA more than 200 are in the high risk of stroke with P-Value <0.05; which was statistically signicant. 4. Conclusion: Prevalence of abnormal cerebral blood ow velocity is high in children with Sickle Cell Anemia which require more availability of transcranial Doppler machine for routine screening of children with SCD. This will help in early identication of children at risk of a Cardio-Vascular Accident for prompt intervention that can avert the deadly complication