ASSESSMENT OF LIVER FUNCTION TESTS AMONG CASES WITH HUMAN IMMUNODEFECIENCY VIRUS (HIV)

Abstract

Background:Co-infection of HIV with HBV and HCV can alter the natural history of these hepatotropic viruses leading to chronic hepatitis, cirrhosis and increases the risk of developing hepatocellular carcinoma. Hence this study was conducted to estimate the sero prevalence of HBV and HCV co-infection among the HIV infected individuals and to assess the association of co-infection with liver enzyme levels and CD4+ T cell levels. Methods: This study was conducted as a cross sectional study in the Department of General medicine in Thanjavur Medical College and hospital, Thanjavur, a tertiary care Government teaching hospital during the period of October 2018 to August 2019.A total of 159 HIV cases were included in the study.All the cases were assessed by detailed history, clinical examination,serology for HIV infection.Patients were tested for co-infection with HBV ,HCV and CD4 count.Data was entered and analysed using Graph Pad Prism version 5 software. Results:BMI was significantly low among cases with HIV associated with co-infection compared to HIV infection alone whereas SGOT, SGPT and ALP were significantly high among cases with HBV co-infection compared to HIV infection alone. Conclusion: This shows that there is higher risk of liver disease among the patients with HIV along with co-infection. The risk is further aggravated by exposure to opportunistic infections, alcoholism and anti retro viral drugs. Hence coinfection with HBV or HCV among the HIV seropositive cases should be estimated earlier before treatment with antiretroviral drugs.