PREVALENCE OF AMPC BETA LACTAMASE PRODUCING ORGANISMS AMONG ADMITTED CAUTI PATIENTS IN A TERTIARY CARE MEDICAL COLLEGE OF EASTERN INDIA.

Abstract

Abstract: AmpC Beta lactamases are class C or group I cephalosporinases that confer resistance to a wide variety of beta lactam antibiotics including cefoxitin, cephalosporins, aztreonam, and are poorly inhibited by beta lactamase inhibitors such as clavulanic acid. Several epidemiological studies have shown that AmpC enzyme producing bacteria are recovered from hospitalized patients after several days of admission to the hospital. Organisms producing these types of beta lactamases often go undetected and therefore have been responsible for several nosocomial outbreak. Hence a study was conducted to see the prevelance of Amp C beta lactamases mainly in CAUTI patients along with the detection method in a tertiary care hospital setup of eastern India among 100 Catheter associated urinary tract infection (CAUTI) cases. The prevalence rate of AmpC beta lactamases was found to be 78.33% by cefoxitin/ cefepime detection method. 81.4% of Ecoli strains and 75.75 % of klebsiellas were AmpC producers in our setup. Study reveals the prevalence of AmpC beta lactamase among CAUTI was relatively high hence antibiotic resistance is an important concern for clinicians treating patients with suspected or confirmed bacterial infections mainly in CAUTI .