ASSESSMENT OF IMMATURE RETICULOCYTE FRACTION (IRF) WITH ABSOLUTE RETICULOCYTE COUNT (ARC) AS A RESPONSE MARKER IN ANTEPARTUM PATIENTS WITH NUTRITIONAL ANEMIA
Author:
Monika M.V.1, Lata Mendiratta Suman2, Dath Suman3
Affiliation:
1. DNB Resident, Hindu Rao Hospital, NDMC Medical College, Delhi -07 2. Senior Gynecologist & HOD (Obst & Gynae), Kasturba Hospital, New Delhi02 3. Assistant. professor (Obst & Gynae), Hindu Rao Hospital, NDMC Medical College, Delhi -07
Abstract
Background: Peripheral blood reticulocyte count is an important index in the diagnosis, classication,
and monitoring of anemic patients. After initiation of therapy, reticulocytosis develops within 3 to 7 days
th th 1
and peaks (8–10%) between the 8 and 10 day . The IRF (Immature Reticulocyte Fraction) increases several days before
reticulocyte count and is thus an early indicator of response to therapy. Aim: To study the response of therapy using IRF on day
rd th th th 3 - 4 and day7 - 8 in antenatal patients with nutritional anemia. To correlate ARC (Absolute Reticulocyte Count) with IRF after
therapy in antenatal patients with nutritional anemia. Study design: Prospective, analytical observational study. Materials
and Methods: A total of 63 pregnant women with nutritional anemia were enrolled. Baseline samples for RBC indices, ARC and
IRF were taken and treated with parental iron and Vit B12 injection accordingly. Baseline, 3rd - 4th and 7th – 8th day of therapy,
values of hematological parameters along with ARC and IRF for predicting the response were determined. Results: The rise in
mean ARC and IRF from baseline to day3/4 and day7/8 is signicantly higher in responders. There was a signicant positive
correlation between IRF and ARC at baseline, day3/4 and day7/8. Conclusion: IRF and ARC increase in nutritional anemia in
subjects, as early as 3-4 days post-therapy, however ARC on day 3-4 is an accurate prediction of response to therapy as
evaluated on day 7-day 8 in the present study
Publisher
World Wide Journals
Subject
Paleontology,Stratigraphy,Geology,Building and Construction,Architecture,Human Factors and Ergonomics,Orthopedics and Sports Medicine,Industrial and Manufacturing Engineering,Polymers and Plastics,Mechanical Engineering,Mechanics of Materials,Civil and Structural Engineering,General Physics and Astronomy,Literature and Literary Theory,Linguistics and Language,Language and Linguistics,Psychiatry and Mental health,Clinical Psychology,Development,Geography, Planning and Development,Health Policy,Economics, Econometrics and Finance (miscellaneous),Literature and Literary Theory,Linguistics and Language
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