AN OBSERVATIONAL ANALYSIS OF CLINICAL PROFILE ASSOCIATED WITH OVULATION INDUCTION USING LETROZOLE AMONG INFERTILE WOMEN WITH POLYCYSTIC OVARIAN SYNDROME

Abstract

Background- Polycystic ovary syndrome (PCOS) is major endocrine and metabolic disease in reproductive women. As per latest procedures, letrozole should be taken as the rst-line pharmacological treatment for infertile women with PCOS. This study was planned to study the role of clinical prole in ovulation induction after letrozole therapy among infertile women with poly- cystic ovarian syndrome. This was a prospective analytical observational study carried out at the IVF centre, SMS Medical College,Methods- Jaipur. The present study enrolled 100 patients attending the IVF centre for fertility treatment who were diagnosed with PCOS as per Rotterdam criteria. Anthropometric measurements like Body mass index (BMI calculated as weight in kilograms divided by square of height in meters) and waist circumference (the smallest circumference at the level of umbilicus) was taken. A comprehensive physical examination of all patients was done to note signs of clinical hyperandrogenism like acne, alopecia, and hirsutism. Treatment response was dened as ovulation in response to letrozole in doses from 2.5 mg to 7.5 mg. In this study, women from 20 to 25 years of age with shorter duration of infertility, lower BMI,Results- lower waist circumference, absence of hirsutism, or mild hirsutism on clinical examination showed better response to Letrozole. Conclusion- Letrozole can be considered a suitable ovulation induction agent in infertile PCOS patients with lower BMI, lower waist circumference, and absence of hirsutism. A predictive ovulation score can be developed from basic clinical parameters. Identication of various factors affecting response to letrozole may help the clinician to individualize ovulation induction protocols in PCOS women.