CLINICOPATHOLOGICAL STUDY OF ORAL SQUAMOUS CELL CARCINOMAS WITH SPECIAL EMPHASIS ON E6, E7 ONCOPROTEIN EXPRESSION AND KI67 LABELLING INDEX

Abstract

Introduction: Oral squamous cell carcinoma (OSCC) comprises of 95 per cent of all oral cancers and these represent approximately 5 per cent of cancers in men and 2 per cent in women. The expression of Ki67 is strongly associated with tumor cell proliferation and growth and is widely used in routine pathological investigation as a proliferation marker. The deregulated expression of the viral E6 and E7 oncoproteins has important role in neoplastic transformation by bypassing of cell cycle checkpoints. The aim of this study is to evaluate the clinicodemographicAims: characteristics, prevalence of HPV infection status, and its correlation with proliferative activity of the tumor cells of OSCC in the Indian study population. This study is Institution Based Observational Cross-Sectional Study conducted in the Department ofMaterial and Methods: Pathology, Medical College, Kolkata from January2018-June2019. 30 cases during the study period are included. Clinical performanceResult: has been signicantly affected by Tumor grade and E6, E7 expression and Ki67 index. A strong statistically signicant association found in between E6/E7 positivity and Ki67 index; the latter being higher among E6/E7 strong positive cases. E6 and E7 alongside Ki67 can beConclusion: used as predictive biomarkers of oral squamous cell carcinomas.