EVALUATION OF ANTI-INFLAMMATORY ACTIVITY OF LEAVES OF AVERRHOEA CARAMBOLA IN EXPERIMENTALANIMAL MODELS

Abstract

To evaluate the anti-inammatory activity of the Ethanolic Extracts of leaves of Averrhoea carambola (EEAC) on experimental animal models. Materials and Methods:The ethanolic extract of Averrhoea carambola leaves was prepared by percolation method using 95% ethanol. For each of the studies four groups of albino ratsof either sex, weighing 100-150g were taken (n = 5). Group A was taken as control, group B and C as test groups, group D as standard. Acute oral toxicity test of the extract was performed as per OECD 425 (OECD Guidelines, 2001). Acute inammation was studied by carrageenan-induced rat paw oedema method and chronic inammation was studied by Freund's complete adjuvant-induced arthritis method. Aspirin 100 mg/kg was taken as a standard drug. Results: The results were analysed by ANOVA followed by Dunnett's multiple comparison test. EEAC at the doses of 200mg/kg and 400 mg/kgshowed signicant (p< 0.01) anti-inammatory activity in carrageenan induced acute inammation when compared to the control. EEAC was also effective in chronic arthritis model in dose-dependent manner. Conclusion:The present study indicates that EEAC has signicant anti-inammatory activity against both acute and chronic inammation.