PLASMA HAEMOGLOBIN AS AN INDICATOR OF HEMOLYSIS IN MALARIA

Abstract

Malaria is major health problem in many tropical and sub-tropical countries, [7] with genus Plasmodium considered to be one of the main killers of man in malaria endemic foci. Red blood cells are the principal sites of infection in malaria. [7] This condition is characterised by hemolysis and thereby altering the levels of plasma haemoglobin. Objective- To assess whole blood and plasma haemoglobin in patients of Malaria and control subjects. Material and Method- 5 ml of blood was collected and divided in 2 EDTAvials , one used for assessment of whole blood haemoglobin and from other vial plasma was separated and processed immediately.Both plasma and whole blood haemoglobin levels were analysed by Drapkin's solution. Result-Whole blood haemoglobin levels were found on lower side( 9.8 ± 1.4 g/dl) where as levels of plasma haemoglobin were high (0.6 ± 0.16 g/dl) in patients of Malaria.Also level of Plasma haemoglobin were high in cases of mixed malaria(0.7 ± 0.08 g/dl) ConclusionAnaemia is very commonly associated nding and altered levels of plasma haemoglobin in Malaria due to hemolysis can leads to several systemic complications and severe organ damage.