PHENOTYPES OF POLYCYSTIC OVARY SYNDROME AND THEIR ASSOCIATION WITH METABOLIC SYNDROME- A NORTH INDIAN TERTIARY CARE CENTER BASED STUDY

Abstract

Background PCOS (Polycystic Ovary Syndrome) is a widely recognized endocrine disorder of the reproductive age group. PCOS women are known to have insulin resistance and an increased tendency for weight gain, leading to an alteration in the metabolic prole. Objectives To categorize women diagnosed as PCOS into various phenotypes and study their correlation with metabolic syndrome. Methods A study was conducted in the department of Obstetrics and Gynecology, GMC Patiala from Jan 2019 to June 2020 and the PCOS were diagnosed and classied into 4 Phenotypes and prevalence of metabolic syndrome as per ATP III/ NCEP criteria was studied in various phenotypes. Results During the study period 116 patients were diagnosed as PCOS. The mean age of the PCOS cases was 24.86 ± 4.96 years (n=116). The PCOS Phenotype A had the maximum prevalence, 52.59%, followed by Phenotype B 18.97%, Phenotype D 16.38%, and Phenotype C 12.06%. The lipid prole was maximally deranged in Phenotype D. The metabolic syndrome was present in 26.72% of cases, with maximum cases belonging to Phenotype A. Conclusion The PCOS cases have a higher prevalence of deranged metabolic proles at a young age. An early multidisciplinary approach in PCOS cases is essential, to lower the prevalence of deranged metabolic prole and long term co-morbidities.