SERUM URIC ACID LEVELAMONG ACUTE CEREBROVASCULAR ACCIDENT PATIENTS IN MANIPUR

Abstract

A large number of studies in the past give conicting results about the role of uric acid as a risk factor in patients with acute cerebrovascular accident (CVA). This study was carried out to measure the level of uric acid among acute cases of CVAand compare it with normal controls and also to nd its relationship with cerebrovascular risk factors. It was a cross sectional study, carried out on 60 patients with acute stroke, admitted in Regional Institute of Medical Sciences (RIMS) hospital , Imphal, from Nov 2018 to Oct 2020. Another 60 healthy individuals were taken as controls. Serum uric acid was measured by Enzymatic Colorimetric method. Mean age of the patients was 58.35+11.54 years. 54 patients were hypertensive, 28 (46.67%) had haemorrhagic stroke and 32 (53.33%) had ischemic stroke. Serum uric acid level was signicantly higher in CVA cases (7.64+2.01)mg/dL compared to controls (5.06+0.98)mg/dL. The level of uric acid was found to be signicantly higher in males (8.55+1.75)mg/dl compared to females (7.64+2.00)mg/dL. Maximum number of the patients had uric acid level >8mg/dl. The level of uric acid was found to be more among the patients with ischemic stroke (7.97+1.87mg/dl) compared to haemorrhagic stroke (7.27+2.13mg/dl). A strong signicant positive correlation was observed with all the lipid parameters and a signicant negative correlation with HDL cholesterol. Increased serum uric acid may be considered as a risk factor of acute cerebrovascular accident.