Affiliation:
1. Pediatric Junior Resident, Narayana Medical College And Hospital, Nellore-524003. Andhra Pradesh
2. Pediatric Junior Resident, Narayana Medical College and Hospital, Nellore- 524003. Andhra Pradesh.
Abstract
Leigh syndrome, also referred to as Sub acute necrotising encephalopathy usually presents with symptoms like developmental delay, regression of
neurological skills and sudden death. Approximately 25% of the patients are abnormal at birth with features like hypotonia, lactic acidosis, feeding
problems, hypoglycemia, hyperbilirubinemia, cardiac complications, seizures and/or hyperammonemia. Here, we present 6 cases of Leigh's
disease , who presented within 6 months of life with neurological regression and hypotonia as the predominent manifestations with MRI ndings
showing Bilateral symmetrical hyperintensities in T2 weighted images which are characteristic ndings in Leigh's disease.
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