A CLINICOPATHOLOGICAL STUDY OF UTERINE LEIOMYOMA IN WOMEN ABOVE 30 YEARS IN A TERTIARY CARE HOSPITAL OF ASSAM

Abstract

Background: Leiomyoma of uterus is the most common benign neoplasm in women. The clinical presentation differs from patients to patients. Due to the complex interactions between steroid hormones, growth hormones and mutations in the myometrium, leiomyoma undergoes degenerative changes and coexists with varied benign and malignant lesions of the endomyometrium and cervix. Aims And Objectives: a) To study the incidence of leiomyoma in hysterectomy specimens. b) To study the histopathological variants and secondary changes in leiomyoma. c) To study the associated histopathological changes in the endomyometrium and cervix. Material And Methods: The present study is conducted in the Department of Pathology, Fakhruddin Ali Ahmed Medical College, Barpeta from July, 2019 to December, 2020. A total of 140 hysterectomy specimens with or without salpingo-oophorectomy of women above 30 years were received. 77 cases diagnosed as leiomyoma on histopathological examination were included in the study and relevant clinical data were analyzed. Result: Uterine leiomyomas occurred mostly in women aged 31-40 years (50.65%). Menorrhagia (58.44%) and dysmenorrhea (32.47%) were the chief clinical manifestations. Most common location was intramural (68.83%). Secondary changes were observed in 20.78% cases of uterine leiomyoma with hyalinization as commonest histopathological nding. Leiomyoma variants was seen in 3.90 % and all of them were cellular leiomyoma. Associated endometrial hyperplasia without atypia (67.53%) and chronic cervicitis (71.42%) was the dominating endometrial and cervical pathology respectively. 33.77% cases had dual pathology of leiomyoma and adenomyosis. Conclusion: A detail and meticulous analysis of the indications for hysterectomy alongwith histopathological ndings play a signicant role in patient management and surveillance.