Affiliation:
1. Department of Anaesthesia and Critical Care, Command Hospital (EC) Kolkata.
2. Department of Pharmacology, Armed Forces Medical College, Pune.
3. Department of Anaesthesia and Critical Care, Command Hospital (EC) Kolkata
Abstract
Introduction: Postoperative nausea and vomiting (PONV) has been variously described as the big little problem, the nal therapeutic challenge
for any anaesthesiologist.
Aims and Objectives: The main aim of this study is to evaluate and compare the antiemetic effects of gabapentin and ondansetron for prevention
of post operative nausea and vomiting (PONV).
Materials and methods: This study was carried out at Command Hospital (Eastern Command), Alipore, Kolkata (operation theatre and ward)
between Jan 2018 – May 2019. Patients of either sex, ASAgrade I and II, age between 20 to 60 years, body weight between 45 to 85 kgs, planned for
Elective laparoscopic cholecystectomy were chosen. PONV in rst 12 hours was measured at 1st hour, 3rd hour, 6th hour and 12th hour, and
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calculation was done based on study carried out by Apfel et al . Taking an alpha error of 0.05 and a power of the study as 90%, the sample size was
worked out as 100 (50 in each group).
Conclusion: The results demonstrated that for decreasing the incidence of PONV, prophylactic use of 600 mg of Gabapentin two hours prior to
planned laparoscopic cholecystectomy is not superior to Ondansetron (which is the standard of care).