A STUDY TO EVALUATE CD44 EXPRESSION IN INVASIVE BREAST CARCINOMA AND ITS CORRELATION WITH HISTOLOGIC GRADE AND PTNM STAGING

Abstract

Introduction: The class mammalian is remarkable for the evolution of modied skin appendages that provide complete nourishment and immunological protection to the young. The breasts form a secondary sexual feature of females and are the source of nutrition for the neonate. They are also present in a rudimentary form in males. Aims And Objectives: Histomorphological study of invasive breast carcinoma on mastectomy specimens and its categorization on the basis ofhistologic grading and PTNM staging. Expression prole of immunohistochemical marker CD44 on invasive breast carcinoma. Correlation between CD44 expression with tumour grade and PTNM staging. Microscopic diagnosis and histopathological analysis of invasive breast carcinoma and its categorization on histologic grading and PTNM staging. Expression of CD44 in invasive breast carcinoma after histopathological diagnosis. Correlation of CD44 expression with that of tumour grade and PTNM staging. Materials And Methods: This study was conducted on a group of patients admitted in Department of General Surgery in collaboration with the Department of Pathology, R G Kar Medical College & Hospital, Kolkata over a period of 18 months. Cross sectional observational descriptive study. Conclusion: The main strength of our study was tertiary care hospital set-up, having infrastructure supportive enough to enable us to study invasive breast carcinoma from various socio-economic background, with diverse mode of presentation. We were able to do the necessary investigations in each case. There were some limitations in our study as limited duration of time, small sample size, unable to follow up results. This study needs to be extrapolated to a large population based sample with nancial support sufcient enough to nd relationship of expression of biomarker with grade and stage of tumour. In short, the present study has revealed various facets of breast carcinomas keeping comparable results with different studies. These ndings need to be conrmed by a larger prospective cohort.