Affiliation:
1. Associate Professor & HOD, Department Of Cardiology, Coimbatore Medical
2. Postgraduate Resident, Department Of Cardiology, Coimbatore Medical College
3. Assistant Professor, Department of Cardiology, Coimbatore medical College.
Abstract
Myocardial infarction causes variable degrees of left ventricular (LV) systolic and diastolic dysfunctions. The ejection fraction (EF) and
transmitral ow are the frequently used method for evaluating the systolic and diastolic functions respectively with considerable limitations. The
MPI is a single independent parameter, capable of estimating both systolic and diastolic performance combined and lacks such limitations. We
enrolled 100 patients presented with a rst acute STEMI who have undergone Thrombolysis. Echocardiography was done within 24 h of chest pain
with measurement of MPI. The LV MPI was calculated as (isovolumic contraction time ''ICT” + relaxation time ''IRT”)/Ejection time ''ET”.
simultaneously, clinical and echocardiographic variables were analyzed and CHF was dened as Killip class >=II. Results: Early in-hospital HF
occurred in 38 of patients (38%). Ejection fraction was found to have a highly signicant negative correlation with the development of in-hospital
HF (p = .0001), while MPI was found to have a highly signicant positive correlation (p = .0001). Acut-off point of MPI > 0.72 showed a very high
specicity (93.6%) and sensitivity (77.3%) for identifying patients with HF. On the other hand, a cut-off point of EF <=32% has shown 93.4%
specicity and 57.5% sensitivity for HF prediction. Conclusions: The MPI might be a strong predictor of in-hospital HF after acute ST elevation
M
Subject
Physiology (medical),Ecology, Evolution, Behavior and Systematics,Physiology,General Biochemistry, Genetics and Molecular Biology,General Earth and Planetary Sciences,Pollution,General Environmental Science,Waste Management and Disposal,Artificial Intelligence,Cognitive Neuroscience,Experimental and Cognitive Psychology,Pharmacology,General Immunology and Microbiology,Applied Microbiology and Biotechnology,General Medicine,Bioengineering,Biotechnology,Cell Biology,Molecular Biology,Pharmacology (medical),Gastroenterology,Oncology,Rheumatology,Immunology and Allergy,General Biochemistry, Genetics and Molecular Biology,General Agricultural and Biological Sciences,General Earth and Planetary Sciences,General Environmental Science
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