Affiliation:
1. Professor And Head, Department Of Plastic And Reconstructive Surgery, Government Medical College, Kozhikode.
2. B.Tech (Genetic Engineering), SRM Institute Of Science And Technology, Kattankulathur
Abstract
Adipocytes are now known to have immense capacity for self-renewal and as well as multipotential
differentiation. Adipose derived stem cells (ADSC) are multipotent stem cells of mesenchymal origin,
located ubiquitously in human body. Unlike the bone marrow stem cells, they are easy to harvest from subcutaneous tissues by
minimally invasive procedures. Several advances in isolation, invitro culture and replication of adipose derived stem cells have
occurred in last decade. Cell assisted lipo-transfers for enhancing the survival of autologous fat grafts (AFG) by enriching them
with ADSC is being practiced in Plastic surgery. Because of their potential for angiogenesis, tissue regeneration,
immunomodulatory and paracrine effects, fat grafts nd considerable applications in Plastic surgery and Regenerative
medicine. This paper explores the current research into applications, techniques of harvest, culture and tissue engineering of
ADSC and the concerns about the oncogenic potentiation and genetic stability of the cultured cell lines.