Affiliation:
1. MD, DNB, Department of Paediatrics, K.V.G. Medical College and Hospital, Sullia, Karnataka.
2. MD, Department of Paediatrics, K.V.G. Medical College and Hospital, Sullia, Karnataka.
Abstract
Background: Perinatal asphyxia is a common neonatal condition and contributes signicantly to
neonatal morbidity and mortality. There is a need to identify neonates with asphyxia who will be at risk for
hypoxic ischemic encephalopathy (HIE) and multi-organ dysfunction. Objectives: To evaluate prospectively the value of
measuring urinary UA/ Cr ratio in early spot urine samples in diagnosing perinatal asphyxia and to assess the relationship
between the urinary UA/Cr ratio and the severity of HIE. Methods: The study was conducted in babies born at K V G medical
college and Hospital, Sullia from October 2018 to May 2020. The urine sample from 55 asphyxiated neonates comprising cases
and 55 comprising controls constituted the material for the study. Results: Urinary uric acid/creatinine ratios were found to be
higher in asphyxiated infants (2.58 ± 0.94) when compared to those in control group (0.87 ± 0.17). The cut-off UUA/Cr value of
1.03 has 92.72% sensitivity with a specicity of 76.36% and has a positive predictive value of 79.68% with a negative predictive
value of 91.30%. Conclusion: UUA/Cr concentration increase after birth asphyxia and is non-invasive, sensitive and costeffective method for assessment of asphyxia and its outcome.
Subject
Paleontology,Stratigraphy,Geology,Building and Construction,Architecture,Human Factors and Ergonomics,Orthopedics and Sports Medicine,Industrial and Manufacturing Engineering,Polymers and Plastics,Mechanical Engineering,Mechanics of Materials,Civil and Structural Engineering,General Physics and Astronomy,Literature and Literary Theory,Linguistics and Language,Language and Linguistics,Psychiatry and Mental health,Clinical Psychology,Development,Geography, Planning and Development,Health Policy,Economics, Econometrics and Finance (miscellaneous),Literature and Literary Theory,Linguistics and Language
Reference8 articles.
1. S Lawn JE, Cousens S, Zupan J. Lancet Neonatal Survival Steering Team. 4 million neonatal deaths: When? Where? Why? Lancet 2005; 365 (9462):891-900.
2. NNPD network. National Neonatal Perinatal Database–report for the year 2002-2003. NNF NNPD network. New Delhi: 2005.
3. Perlman JM, Tack ED, Martin T, et al. Acute systemic organ injury in term infants after asphyxia. Am J Dis Child 1989; 143:617-620.
4. Snyder EY, Cloherty JP. Perinatal Asphyxia. In: cloherty JP,Stark Ann R, editors. Manual of Neonatal Care, 4ed. (Philadelphia: Lippincott Raven Publishers, 1998): p 530.
5. Manzke H, Dörner K, Grünitz J. Urinary hypoxanthine, xanthine and uric acid excretion in newborn infants with perinatal complications. Acta Paediatr Scand. 1977;66(6):713-7.