THE STUDY OF SUBLINGUAL, ORALAND VAGINALADMINISTRATION OF MISOPROSTOL IN REGRESSION OF SYMPTOMS OF MISSED ABORTION

Abstract

Background: Misoprostol is a widely popularly used drug in treatment of missed abortions. It is very simple to use, easily available and has an average efciency greater than 90%. Adrug this popular and versatile needs better study to improve its efciency and minimize all possible adverse unwanted effects. Hence the idea to make a comparative study between the different modes of administration of Misoprostol was arrived upon so as to understand it in a much better way. Aim: A comparison of the efcacy of Misoprostol used in sublingual, oral and vaginal routes for missed abortion. Material and methods: The study was conducted at the Department of Obstetrics and Gynaecology in Nilratan Sircar Medical College and Hospital, Kolkata after approval by the ethical committee. The sample size was 100 women being treated for missed abortions where prospective sampling was carried out to determine the candidates to be selected for the study. Single centred, institution based, randomized controlled trial. Cases included in this study were divided into 3 groups: Sublingual Group, Oral Group and Vaginal Group. Result: It was found that in oral, 4(11.8%) patients had fever. In sublingual, 6(17.6%) patients had fever. In vaginal, 2(5.9%) patients had fever. Association of fever vs. group was not statistically signicant (p=0.3220). Conclusion: The study demonstrates that both vaginal and sublingual misoprostol have similar and higher success rates in inducing abortion compared to oral route