A CASE REPORT AND LITERATURE REVIEW: METACHRONOUS TUMOUR IN SINGLE PATIENT (CARCINOMA CERVIX AND CARCINOMA LUNG)

Abstract

INTRODUCTION: - Multiple primary tumors can be synchronous when detected simultaneously (or) metachronous when detected after a variable time interval. Association of two cancer in same patient is unusual but has been widely reported in the literature. CASE PRESENTAION: - A 55-year-old women was diagnosed in December 2018 as squamous cell carcinoma cervix FIGO STAGE IIIB & she received denitive chemoradiation 46GY/23# for 5 weeks with 5 cycles weekly injection carboplatin under AUC 2 followed by Brachytherapy and completed treatment in February 2019. She was on regular follow up till December 2020. Later she presented with upper back pain. She was evaluated for the same. CT Thorax suggestive of right upper lobe lung mass and PET- CT S/O Right Lung mass lesion with extension into spinal rd th canal & lytic destruction of D2/D3 Vertebrae and Right 3 , 4 rib. CT guided Biopsy s/o squamous cell carcinoma with IHC- p16 & p40-Positive, nd TTF-Negative and diagnosed as 2 primary carcinoma lung Stage IV. She received 6 cycles systemic chemotherapy completed in May 2021. She improved clinically & radiologically with systemic chemotherapy paclitaxel & carboplatin. CONCLUSION: - Metachronous tumor in single patient is unusual & management depends on stage of presentation.