ANTIMICROBIAL RESISTANCE PATTERNS IN ARTHRITIS GOUT PATIENTS WITH INFECTION

Abstract

Background: Gout arthritis is a metabolic disease characterized by the accumulation of monosodium urate (MSU) in the joints and soft tissues that cause inammation. If this inammatory process continues it will cause severe pain that can decrease the quality of life. The incidence of gout arthritis disease increases from year to year and often coincides with infectious arthritis so analysis of infected joint uid aspiration is essential to establish an accurate diagnosis and initiate appropriate antimicrobial therapy. The limited data on antimicrobial resistance patterns in gout arthritis patients in Indonesia is the basis for this study. Objective: To investigate the pattern of antimicrobial resistance in gout arthritis patients with infection. Methods: Descriptive research was conducted at Haji Adam Malik General Hospital Medan and Boloni Hospital from April to July 2018 with 20 samples of gout arthritis patients with infection. Results: 20 patients with gout arthritis who had infection, with the most sex was male (60%) with mean age 52,1 ± 9,25 years old and mean of uric acid level 10,01 ± 1,73 mg/ dL. The most common microorganisms identied were Acinetobacter baumanii and Escherichia coli. Cefazolin, Ciprooxacin and Ampicillin are antimicrobials with high resistance rates ≥ 80% in this study. Conclusion: Acinetobacter baumanii and Escherichia coli are the most common microorganisms in gout arthritis patients with infections at RSUP H. Adam Malik Medan and RS Boloni Medan whereas high-resistance antimicrobials are Cefazolin, Ciprooxacin and Ampicillin