Affiliation:
1. MD, Associate Professor of Anesthesiology, Dept. of Anesthesiology, Kurnool Medical College / GGH, Kurnool.
Abstract
The physiological response to surgical stress and anaesthesia is well documented. Laparoscopic surgery which involves insufflation with carbon dioxideproduces undesirable responses like hypertension, tachycardia and dysrhythmias. Introduction of Dexmedetomidine which is highly specific and selectiveα2 adrenoceptor agonist has been tried in various studies to modify the stress response to surgery and to have a pleasant anaesthetic outcome with minimal cardiovascular changes. In our present study we have taken the pharmacological advantage of Dexmedetomidine to study the various cardiovascular parameters at different periods during the laparoscopic procedure. The aim is to studythe effectiveness of Dexmedetomidineinattenuating the sympathetic response tolaryngoscopy and endotracheal intubation and in maintaining the hemodynamic stability in laparoscopic cholecystectomy.
Materials & Methods:
30 ASA I and II patients of either sex, scheduled for elective Laparoscopic Cholecystectomy under General anaesthesia were randomly allocated to receive either 1mcg/kg of Dexmedetomidine in 100ml of 0.9% normal saline (Group D,n=30) or 100ml of 0.9% normal saline(Group S, n=30) 30min beforeinduction.
Results:
In patients who received Dexmedetomidine there was a statistically significant differencein heartrate, systolic blood pressure, diastolic blood pressure and meanarterial pressures during Laparoscopy and Intubation.
Conclusion:
Dexmedetomidine when given as a premedication before Laparoscopic Cholecystectomy attenuates the sympathetic response to laryngoscopy and intubation and provides stable intra operative hemodynamics.