COMPARATIVE STUDY OF NIFEPIDINE AND ISOXSUPRINE IN SUPPRESSION OF PRETERM LABOUR IN THIRD TRIMESTER-Reference-Cited by-同舟云学术

COMPARATIVE STUDY OF NIFEPIDINE AND ISOXSUPRINE IN SUPPRESSION OF PRETERM LABOUR IN THIRD TRIMESTER

Published:2020-09-01 Issue: Volume: Page:1-2
ISSN:
Container-title:INTERNATIONAL JOURNAL OF SCIENTIFIC RESEARCH
language:en
Short-container-title:ijsr

Author:

Kumari Priyanka¹,Sinha Anupama²,Jana Debarshi³

Affiliation:

1. M.S. (Obs. & Gynae.), Senior Resident, Department of Obstetrics and Gynaecology, Jawaharlal Nehru Medical College and Hospital, Bhagalpur, Bihar.

2. M.S., DNB (Obs. & Gynae.), Associate Professor, Department of Obstetrics and Gynaecology, Jawaharlal Nehru Medical College and Hospital, Bhagalpur, Bihar.

3. Young Scientist (DST), Institute of Post-Graduate Medical Education and Research, A.J.C. Bose Road, Kolkata-700020, West Bengal, India

Abstract

Background: A prospective study was conducted to compare the efficacy of nifedipine against isoxsuprine in preventing preterm labour in third trimester and also to evaluate maternal side effects and neonatal outcome. Methods: This prospective comparative study was conducted at JLNMCH, Bhagalpur, Bihar. 75 antenatal women with gestational age between 28 to 36 weeks wereselected who fulfilled the inclusion criteria for the study, were given nifedipine and were monitored throughout thecourse of treatment. Results: Groups were compared with mean prolongation of delivery, side effects, neonatal outcome, parity, cervicaleffacements. Nifedipine was twice more effective than isoxsuprine hydrochloride as a uterine tocolytic agent whileside effects were comparable with fewer side effects in nifedipine group. Neonatal outcome was better with nifedipinein comparison to isoxsuprine. Conclusions: There is a high incidence of preterm labour in India. The present study found that nifedipine has bettertocolytic efficacy, less side effects and better tolerability as compared to isoxsuprine in third trimester.

Publisher

World Wide Journals

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