STUDY OF PROGNOSTIC INDICATORS IN PATIENTS WITH CIRRHOSIS OF LIVER WITH ASCITIS AND SPONTANEOUS BACTERIAL PERITONITIS

Abstract

Spontaneous bacterial peritonitis(SBP) is dened as ascitic uid infection in the absence of any obvious intraabdominal source of infection. The mortality rate is approximately 30-50% The objective of this study is to study predictors of mortality on patients with spontaneous bacterial peritonitis in cirrhosis of liver patients. Methods: Fifty patients diagnosed with cirrhosis of liver reporting to ACSR GGH, Nellore were included in the study. SBPwas diagnosed based on ascitic uid ascitic uid PMN count >250. Serial ascitic uid cell count was done at 24 hours, 48 hours and 5 days.The results were compared between survivors and non survivors. Results: Male: female ratio was 2:1.Study showed 42% mortality. TLC above 11000/mm3,total bilirubin above > 4 mg/dl, serum creatinine >1.5 were associated with increased mortality .Interpretation & Conclusion: Ascitic uid PMN count > 600 at the time of diagnosis, 700 at 24 hrs, 450 at 48 hrs was associated with poor prognosis. AProgressive fall in serial ascitic uid cell PMN count was associated with good prognosis