A STUDY ON EXPRESSION PROFILE OF BASAL MARKER CD44 AND LUMINAL MARKER CK20 IN UROTHELIAL NEOPLASM AND ITS CORRELATION WITH WHO GRADING AND STAGING OF TUMOUR

Abstract

Aim: Histomorphological study of urothelial carcinoma on TRBT and Cystectomy specimen and its categorization on the basis of WHO grading & pTNM staging and to nd out the correlation between CK20 and CD44 exprression with tumour grade, pTNM staging. Material And Method: This descriptive cross sectional prospective study was conducted in the Department of Pathology, R G Kar Medical College & Hospital Kolkata in collaboration with Department of Urosurgery, R G Kar Medical College & Hospital, Kolkata, West Bengal. The present study is intended to nd out over expression of CD44 & CK20 in Urothelial Carcinoma of Bladder and correlate with tumour grade and clinical features. Result: There is strong association between CD44, CK20 expression and Stage of Urothelial Carcinoma cases and had a strong association between CD44 expressions and grade Urothelial Carcinoma cases. Conclusion: CK20 overexpression was seen more signicantly in High Grade tumours HGPUC (p < 0.05) as well as advanced stage pT2 and CD44 overexpression was more signicantly in lower grade tumours LGPUC (p<0.05) as well as lower stages pT1 in urothelial carcinoma. An inverse relasionship was noted in the staining patterns of CK20 and CD44 within individual cases as well as aggregate data,with (68.24%) of tumours with CD44 loss showing CK20 positivity.