A STUDY ON THE OUTCOME OF COMBINATION THERAPY OF ASPIRIN AND ATORVASTATIN IN IMPROVEMENT OF ANKLE BRACHIAL PRESSURE INDEX AMONG PATIENTS WITH PERIPHERAL VASCULAR DISEASE IN A TERTIARY CARE CENTRE, SOUTH KERALA

Abstract

Background: Peripheral Artery Disease is quite common in the old age group patients in our population. This has to be detected in a early stage so that starting of prophylactic medication with Aspirin and Statin will prevent further progression of the disease , it also prevent the death due to cardiac events in our population. Objectives 1. To study the outcome of combination therapy of Aspirin and Atorvastatin in PAD patients by improvement in ankle brachial pressure index 2. To nd the correlation between cholesterol level and ABPI in peripheral arterial disease. Materials and methods: A hospital-based observational study involving 55 patients was conducted in the Department of General surgery, Dr. SMCSI Medical College Karakonam, Trivandrum during December 2013 to October 2015. Data about the patient's age, sex, clinical symptoms, co morbidities, addictions and ABPI in each month, after starting Aspirin and Atorvastatin are collected with informed consent from the patient. Cholesterol level in the initial and after 6 months was compared. A total of 55 adult male or female participants ≥31 years of age (meanResults: age: 62.76 ± 10.79) years; 67.3% male and 32.7% female) were evaluated. Among the total participant 26.9% the affected side was right. 37.3% the affected side was left and for 35.8% both the sides were affected. In this study the mean difference between Ankle Brachial Pressure Index of rst and sixth month is 0.12 with SD = 0.09 (P value <0.001). Thus, there was signicant improvement both statistically and clinically in the Ankle Brachial Pressure Index (p value <0.001). Effect of combination therapy with Aspirin and Atorvastatin has a major role in treatingConclusion: PAD patients. It also reduces the incidence of cardiac problems like angina, myocardial infarction.