A COMPARATIVE STUDY OF TOLVAPTAN (15 MG AND 30 MG) TO PREVENT HYPONATREMIA IN TRANSURETHRAL RESECTION OF PROSTATE SURGERY-A RANDOMIZED DOUBLE BLIND STUDY

Abstract

Purpose:The aim of our study is to compare two doses of tolvaptan in prevention of hyponatremia in transurethral resection of prostate surgery. Materials and Methods: This is randomized double-blind study conducted in 60 ASA grade status 1 and 2 patients age group between 45-80 yrs undergoing TURP under spinal anaesthesia in urology operation theatre in Mahatma Gandhi hospital Jaipur after receiving permission from hospital ethical committee. A detailed history, complete physical examination and routine investigation were done for all patients followed by informed written consent was obtained. Patients are randomly divided into 2 groups. In group A -30 patients who received orally tab tolvaptan 15 mg and group B-30 patients who received orally tab tolvaptan 30 mg 2 hrs before surgery after doing electrolytes of the patients in the morning. In both groups age (in yrs), wt (in kg), ASAgrade, volume of irrigating uid (in litres), volume of prostate resected (in gm) and duration of surgery (in minutes) all demographic and surgical details data were compared. Electrolytes were compared in both groups pre and post-operatively and statistical analysis was done. Results:There was signicant difference in post-operative sodium level between the two groups (Aand B). The mean level of sodium signicantly reduced post-operatively in group –A (tolvaptan 15mg grp). The mean level of sodium signicantly increased post-operatively in group –B (tolvaptan 30mg grp). Conclusion:We conclude single dose of tolvaptan 30 mg found to effective in prevention of hyponatremia in patients undergoing TURP.