“A COMPARATIVE STUDY TO EVALUATE THE EFFICACY OF IN POSTOPERAT ETORICOXIB IN PAIN RELIEF IN PATIENTS IN UNDERGOING LUMBAR SPINE SURGERY ”

Abstract

AIMS AND OBJECTIVES: To evaluate the efcacy of Etoricoxib in different doses in postoperative pain relief in patients undergoing lumbar spine surgery. MATERIALAND METHOD : 80 patients of ASA grade І & ІІ of either sex scheduled for lumbar spine surgery under general anaesthesia were divided into 2 groups (n=40 each) randomly.Group E (n=40) Patients who received a 90 mg Etoricoxib 1 hour before surgery and another tablet the following morning. Group 'P'(n=40) Patients who received a placebo tablet 1 hour before surgery and again the following morning. Pulse rate, blood pressure, respiratory rate and severity of pain on NRS scale was noted at 0 hr, 4 hr, 8 hr, 12 hr, 16 hr, 20 hr, 24 hr, 28 hr, 32 hr and 48 hr after surgery. And the presence or absence of adverse effects, such as headache, nausea, vomiting, dizziness, and drowsiness were noted. RESULT:Analysis revealed that time for rst analgesic requirement was signicantly longer with oral Etoricoxib 90 mg than with placebo. Pre-emptive oral Etoricoxib 90 mg decreases the severity of pain postoperatively but not signicantly as compared to placebo in patients posted for lumbar spine surgery under general anaesthesia. Oral Etoricoxib 90 mg had no signicant effect on cardiovascular and respiratory parameters. Patients receiving Etoricoxib had higher incidence of nausea, vomiting. CONCLUSION: that time for rst analgesic requirement was signicantly longer with oral Etoricoxib than placebo.