DIAGNOSIS OF ROSAI-DORFMAN DISEASE BY FINE NEEDLE ASPIRATION CYTOLOGY- A STUDY OF ELEVEN CASES WITH EMPHASIS ON SITE

Author:

Surendranath Rinsha1,Rajani M2

Affiliation:

1. Post Graduate, Department of Pathology, Govt. Siddhartha Medical College, Andhra Pradesh ,India.

2. Department of Pathology, Govt. Siddhartha Medical College, Andhra Pradesh ,India.

Abstract

Rosai Dorfman Disease also called as Sinus Histiocytosis with Massive Lymphadenopathy is a benign proliferative disorder of histiocytes which typically affects lymph nodes of cervical region ,however extranodal sites are also being reported by many authors[1].FNAC is the investigation of choice as is it less invasive and more reliable.Aims :To study the various sites of involvement and diagnostic significance of FNAC along with the pattern of site and age distribution .We studied a series of 11 cases for a period of one year.Materials and methods: Eleven cases studied in the department of Pathology Govt. Siddhartha Medical College,Vijayawada.Material collected from Govt. General Hospital,Vijayawada.Results:The present study showed two extranodal,one axillary lymph node,one inguinal lymph node and seven cervical lymph node involment.Conclusion:Rosai- dorfman disease main clinical manifestion is cervical lymph node enlargement ,but other lymph nodes and extranodal site can also be involved.Most common age of presentation was between 20-40years

Publisher

World Wide Journals

Reference17 articles.

1. Foucar E,Rosai J,DorfmanR: Sinus hisatopcytosis with massive lymphadenopathy (Rosai and Dorfman disease):review of the entity .Semin Diag Pathol 1990;7:19-73.

2. Destombes P.Adenitis with lipid excess,in children or young adults seen in the Antilles and mali.(4 cases).Boll soc Pathol Exot Filiales;1965;58:1169-75

3. Rosai J Sinus histiocytosis with massive lymphadenopathy:A newly recognised benign cytopathological entity.Arch Pathol1969;87:63-70

4. Levine PH ,Jahan N,Murari P,Manak M,Jaffe ES:Detection of human herpes Virus 6 in tissues involved by Sinus histiocytosis with massive Lymphadenopathy(Rosai dorfman disease).J Infect Dis1992:16:291-295.

5. Mehraein Y,Wagner M,Remberger K, et al: Parvo virus B19 detected in Rosai dorfman disease nodal and extranodal manifestations. J clin Pathol 2006;59:1320-1326.

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